Wnt/β-catenin signaling: The culprit in pancreatic carcinogenesis and therapeutic resistance

Monish Ram Makena, Himavanth Gatla, Dattesh Verlekar, Sahithi Sukhavasi, Manoj K. Pandey, Kartick C. Pramanik

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is responsible for 7.3% of all cancer deaths. Even though there is a steady increase in patient survival for most cancers over the decades, the patient survival rate for pancreatic cancer remains low with current therapeutic strategies. The Wnt/β-catenin pathway controls the maintenance of somatic stem cells in many tissues and organs and is implicated in pancreatic carcinogenesis by regulating cell cycle progression, apoptosis, epithelial-mesenchymal transition (EMT), angiogenesis, stemness, tumor immune microenvironment, etc. Further, dysregulated Wnt has been shown to cause drug resistance in pancreatic cancer. Although different Wnt antagonists are effective in pancreatic patients, limitations remain that must be overcome to increase the survival benefits associated with this emerging therapy. In this review, we have summarized the role of Wnt signaling in pancreatic cancer and suggested future directions to enhance the survival of pancreatic cancer patients.

Original languageEnglish (US)
Article number4242
JournalInternational Journal of Molecular Sciences
Volume20
Issue number17
DOIs
StatePublished - Sep 1 2019

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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