Withdrawal from a single exposure to cocaine increases 5-HT2A receptor and G protein function

Gonzalo A. Carrasco, George Battaglia

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We previously reported that withdrawal from chronic cocaine produces supersensitivity of serotonin 2A receptors. We report here the minimum cocaine exposure necessary to produce withdrawal-associated increases in serotonin 2A receptor signaling in the frontal cortex. Rats withdrawn from cocaine treatments of 1, 3 or 7 days exhibited increases in G protein-stimulated and serotonin 2A receptor-stimulated phospholipase C activity in the frontal cortex. A single cocaine injection produced withdrawal-induced changes comparable to that produced by repeated exposure. None of these cocaine treatment paradigms are associated with changes in the levels of serotonin 2A receptors, Gαq or Gα11 proteins. These data demonstrate that only a single exposure to cocaine can produce unique withdrawal-associated neuroadaptations in serotonin 2A receptor signaling in the frontal cortex, which may be clinically relevant with respect to drug relapse.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalNeuroReport
Volume18
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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