Why do SARS-CoV-2 NSPs rush to the ER?

Maryline Santerre, Sterling P. Arjona, Charles Ns Allen, Natalia Shcherbik, Bassel E. Sawaya

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

SARS-CoV-2, which led to the 2020 global pandemic, is responsible for the Coronavirus Disease 2019 (COVID-19), a respiratory illness, and presents a tropism for the central nervous system. Like most members of this family, the virus is composed of structural and non-structural proteins (NSPs). The non-structural proteins are critical elements of the replication and transcription complex (RTC), as well as immune system evasion. Through hijacking the endoplasmic reticulum (ER) membrane, NSPs help the virus establish the RTC, inducing ER stress after membrane rearrangement and causing severe neuronal disturbance. In this review, we focus on the role of Nsp3, 4, and 6 in intracellular membrane rearrangement and evaluate the potential disruption of the central nervous system and the neurodegeneration which it could trigger. Studies of these NSPs will not only bring to light their specific role in viral infection but also facilitate the discovery of novel targeted drugs.

Original languageEnglish (US)
Pages (from-to)2013-2022
Number of pages10
JournalJournal of Neurology
Volume268
Issue number6
DOIs
StatePublished - Jun 2021

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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