Visuospatial performance in patients with statistically-defined mild cognitive impairment

Victor Wasserman, Sheina Emrani, Emily F. Matusz, Jamie Peven, Seana Cleary, Catherine C. Price, Terrie Beth Ginsberg, Rodney Swenson, Kenneth M. Heilman, Melissa Lamar, David J. Libon

Research output: Contribution to journalArticle

Abstract

Introduction: The Oblique Effect denotes superior performance for perceiving horizontal or vertical rather than diagonal or oblique stimuli. The current research investigated responding to oblique test stimuli in patients with mild cognitive impairment (MCI). Method: Four statistically-determined groups (n = 112) were studied; patients with little to no cognitive impairment (non-MCI, n = 39); subtle cognitive impairment (SCI, n = 15); amnestic MCI (aMCI, n = 28); and a combined mixed/dysexecutive MCI (mixed/dys MCI, n = 30). The ability to respond to oblique versus non-oblique test stimuli was assessed using the Judgment of Line Orientation Test (JOLO). Comprehensive neuropsychological assessment was also obtained. Between-group differences for JOLO oblique and non-oblique test stimuli were analyzed. Hierarchical linear regression models were constructed to identify relations between accuracy for oblique and non-oblique test items and neurocognitive domains. Results: The mixed/dys MCI group demonstrated lower accuracy for oblique test items compared to non-MCI patients. Accurate responding to oblique test items was associated with better performance on tests measuring executive control, processing speed, naming/lexical retrieval, and verbal concept formation. No between-group differences were seen for non-oblique items and these items were not associated with cognition. Conclusions:Significant impairment on oblique test items distinguished patients with multi-domain/dysexecutive MCI from non-MCI patients. Accurate responding to oblique test items was associated with a complex array of neuropsychological tests suggesting that multidimensional neuropsychological skills underlie the visuospatial reasoning abilities necessary for successful oblique line identification. Research associating responding to oblique versus non-oblique test stimuli using additional neuropsychological test paradigms, and MRI-defined neuroanatomical regions of interest may provide additional information about the brain-behavior relations that underlie MCI subtypes.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalJournal of Clinical and Experimental Neuropsychology
Volume42
Issue number3
DOIs
StatePublished - Mar 15 2020

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

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    Wasserman, V., Emrani, S., Matusz, E. F., Peven, J., Cleary, S., Price, C. C., Ginsberg, T. B., Swenson, R., Heilman, K. M., Lamar, M., & Libon, D. J. (2020). Visuospatial performance in patients with statistically-defined mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology, 42(3), 319-328. https://doi.org/10.1080/13803395.2020.1714550