Visuoconstructional Impairment in Subtypes of Mild Cognitive Impairment

Samrah Ahmed, Laura Brennan, Joel Eppig, Catherine C. Price, Melissa Lamar, Lisa Delano-Wood, Katherine J. Bangen, Emily C. Edmonds, Lindsey Clark, Daniel A. Nation, Amy Jak, Rhoda Au, Rodney Swenson, Mark W. Bondi, David J. Libon

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Clock Drawing Test performance was examined alongside other neuropsychological tests in mild cognitive impairment (MCI). We tested the hypothesis that clock-drawing errors are related to executive impairment. The current research examined 86 patients with MCI for whom, in prior research, cluster analysis was used to sort patients into dysexecutive (dMCI, n = 22), amnestic (aMCI, n = 13), and multidomain (mMCI, n = 51) subtypes. First, principal components analysis (PCA) and linear regression examined relations between clock-drawing errors and neuropsychological test performance independent of MCI subtype. Second, between-group differences were assessed with analysis of variance (ANOVA) where MCI subgroups were compared to normal controls (NC). PCA yielded a 3-group solution. Contrary to expectations, clock-drawing errors loaded with lower performance on naming/lexical retrieval, rather than with executive tests. Regression analyses found increasing clock-drawing errors to command were associated with worse performance only on naming/lexical retrieval tests. ANOVAs revealed no differences in clock-drawing errors between dMCI versus mMCI or aMCI versus NCs. Both the dMCI and mMCI groups generated more clock-drawing errors than the aMCI and NC groups in the command condition. In MCI, language-related skills contribute to clock-drawing impairment.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalApplied Neuropsychology:Adult
Volume23
Issue number1
DOIs
StatePublished - Jan 2 2016

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology

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