TY - GEN
T1 - Visualization and classification of microarray gene data by nonnegtive matrix factorization
AU - Kong, Wei
AU - Mou, Xiaoyang
AU - Tao, Weijie
AU - Xia, Yao
PY - 2010
Y1 - 2010
N2 - Gene microarray technology is an effective tool to collect the expression levels of thousands of genes from a single array. However, exploitation of the huge amount of data generated by microarrays is difficult because they are complex and noisy high-dimensional data. In this work, we present a biclustering method nonnegtive matrix factorization (NMF) to reduce the dimensionality of the data and discover the underlying biological process from gene expression data of Alzheimer's disease (AD). The simulation results show that the reduction of dimension and identification of informatively biological process are useful for both visualization and analyzing of such high-throughput gene dataset.
AB - Gene microarray technology is an effective tool to collect the expression levels of thousands of genes from a single array. However, exploitation of the huge amount of data generated by microarrays is difficult because they are complex and noisy high-dimensional data. In this work, we present a biclustering method nonnegtive matrix factorization (NMF) to reduce the dimensionality of the data and discover the underlying biological process from gene expression data of Alzheimer's disease (AD). The simulation results show that the reduction of dimension and identification of informatively biological process are useful for both visualization and analyzing of such high-throughput gene dataset.
UR - http://www.scopus.com/inward/record.url?scp=79951746124&partnerID=8YFLogxK
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U2 - 10.1109/ISPACS.2010.5704740
DO - 10.1109/ISPACS.2010.5704740
M3 - Conference contribution
AN - SCOPUS:79951746124
SN - 9781424473717
T3 - ISPACS 2010 - 2010 International Symposium on Intelligent Signal Processing and Communication Systems, Proceedings
BT - ISPACS 2010 - 2010 International Symposium on Intelligent Signal Processing and Communication Systems, Proceedings
T2 - 18th International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2010
Y2 - 6 December 2010 through 8 December 2010
ER -