Viral-based gene transfer to the mammalian CNS for functional genomic studies

Christopher G. Janson, Scott W.J. McPhee, Paola Leone, Andrew Freese, Matthew J. During

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

A fundamental problem in neuroscience has been the creation of suitable in vivo model systems to study basic neurological phenomena and pathology of the central nervous system (CNS). Somatic cell genetic engineering with viral vectors provides a versatile tool to model normal brain physiology and a variety of neurological diseases.

Original languageEnglish (US)
Pages (from-to)706-712
Number of pages7
JournalTrends in Neurosciences
Volume24
Issue number12
DOIs
StatePublished - Dec 1 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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