TY - JOUR
T1 - Verbal serial list learning in mild cognitive impairment
T2 - A profile analysis of interference, forgetting, and errors
AU - Libon, David J.
AU - Bondi, Mark W.
AU - Price, Catherine C.
AU - Lamar, Melissa
AU - Eppig, Joel
AU - Wambach, Denene M.
AU - Nieves, Christine
AU - Delano-Wood, Lisa
AU - Giovannetti, Tania
AU - Lippa, Carol
AU - Kabasakalian, Anahid
AU - Cosentino, Stephanie
AU - Swenson, Rod
AU - Penney, Dana L.
PY - 2011/9
Y1 - 2011/9
N2 - Using cluster analysis Libon et al. (2010) found three verbal serial list-learning profiles involving delay memory test performance in patients with mild cognitive impairment (MCI). Amnesic MCI (aMCI) patients presented with low scores on delay free recall and recognition tests; mixed MCI (mxMCI) patients scored higher on recognition compared to delay free recall tests; and dysexecutive MCI (dMCI) patients generated relatively intact scores on both delay test conditions. The aim of the current research was to further characterize memory impairment in MCI by examining forgetting/savings, interference from a competing word list, intrusion errors/perseverations, intrusion word frequency, and recognition foils in these three statistically determined MCI groups compared to normal control (NC) participants. The aMCI patients exhibited little savings, generated more highly prototypic intrusion errors, and displayed indiscriminate responding to delayed recognition foils. The mxMCI patients exhibited higher saving scores, fewer and less prototypic intrusion errors, and selectively endorsed recognition foils from the interference list. dMCI patients also selectively endorsed recognition foils from the interference list but performed similarly compared to NC participants. These data suggest the existence of distinct memory impairments in MCI and caution against the routine use of a single memory test score to operationally define MCI.
AB - Using cluster analysis Libon et al. (2010) found three verbal serial list-learning profiles involving delay memory test performance in patients with mild cognitive impairment (MCI). Amnesic MCI (aMCI) patients presented with low scores on delay free recall and recognition tests; mixed MCI (mxMCI) patients scored higher on recognition compared to delay free recall tests; and dysexecutive MCI (dMCI) patients generated relatively intact scores on both delay test conditions. The aim of the current research was to further characterize memory impairment in MCI by examining forgetting/savings, interference from a competing word list, intrusion errors/perseverations, intrusion word frequency, and recognition foils in these three statistically determined MCI groups compared to normal control (NC) participants. The aMCI patients exhibited little savings, generated more highly prototypic intrusion errors, and displayed indiscriminate responding to delayed recognition foils. The mxMCI patients exhibited higher saving scores, fewer and less prototypic intrusion errors, and selectively endorsed recognition foils from the interference list. dMCI patients also selectively endorsed recognition foils from the interference list but performed similarly compared to NC participants. These data suggest the existence of distinct memory impairments in MCI and caution against the routine use of a single memory test score to operationally define MCI.
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U2 - 10.1017/S1355617711000944
DO - 10.1017/S1355617711000944
M3 - Article
C2 - 21880171
AN - SCOPUS:82455185968
SN - 1355-6177
VL - 17
SP - 905
EP - 914
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 5
ER -