Valvular Cytomegalovirus Endocarditis

Timothy J. Stear; David Shersher; George J. Kim; Douglas R. Smego

doi:10.1016/j.athoracsur.2016.01.074

Valvular Cytomegalovirus Endocarditis

Timothy J. Stear, David Shersher, George J. Kim, Douglas R. Smego

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Endocarditis is a rare presentation for cytomegalovirus (CMV) infection. We present the case of a 49-year-old man who underwent mitral and tricuspid valve replacement for valvular CMV endocarditis. The patient's past medical history was significant for human immunodeficiency virus, intravenous drug abuse, and chronic hepatitis B. During his clinical course, he was found to have tricuspid and mitral valve vegetations. After progressive valvular destruction despite antibiotic therapy, he underwent successful mitral and tricuspid valve replacement. Pathologic analysis of the culture-negative valve specimens were found to contain inclusion bodies consistent with CMV, and quantitative serum polymerase chain reaction returned a highly elevated CMV DNA count.

Original language	English (US)
Pages (from-to)	e105-e107
Journal	Annals of Thoracic Surgery
Volume	102
Issue number	2
DOIs	https://doi.org/10.1016/j.athoracsur.2016.01.074
State	Published - Aug 1 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.athoracsur.2016.01.074

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title = "Valvular Cytomegalovirus Endocarditis",

abstract = "Endocarditis is a rare presentation for cytomegalovirus (CMV) infection. We present the case of a 49-year-old man who underwent mitral and tricuspid valve replacement for valvular CMV endocarditis. The patient's past medical history was significant for human immunodeficiency virus, intravenous drug abuse, and chronic hepatitis B. During his clinical course, he was found to have tricuspid and mitral valve vegetations. After progressive valvular destruction despite antibiotic therapy, he underwent successful mitral and tricuspid valve replacement. Pathologic analysis of the culture-negative valve specimens were found to contain inclusion bodies consistent with CMV, and quantitative serum polymerase chain reaction returned a highly elevated CMV DNA count.",

author = "Stear, \{Timothy J.\} and David Shersher and Kim, \{George J.\} and Smego, \{Douglas R.\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Society of Thoracic Surgeons",

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AU - Stear, Timothy J.

AU - Shersher, David

AU - Kim, George J.

AU - Smego, Douglas R.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Endocarditis is a rare presentation for cytomegalovirus (CMV) infection. We present the case of a 49-year-old man who underwent mitral and tricuspid valve replacement for valvular CMV endocarditis. The patient's past medical history was significant for human immunodeficiency virus, intravenous drug abuse, and chronic hepatitis B. During his clinical course, he was found to have tricuspid and mitral valve vegetations. After progressive valvular destruction despite antibiotic therapy, he underwent successful mitral and tricuspid valve replacement. Pathologic analysis of the culture-negative valve specimens were found to contain inclusion bodies consistent with CMV, and quantitative serum polymerase chain reaction returned a highly elevated CMV DNA count.

AB - Endocarditis is a rare presentation for cytomegalovirus (CMV) infection. We present the case of a 49-year-old man who underwent mitral and tricuspid valve replacement for valvular CMV endocarditis. The patient's past medical history was significant for human immunodeficiency virus, intravenous drug abuse, and chronic hepatitis B. During his clinical course, he was found to have tricuspid and mitral valve vegetations. After progressive valvular destruction despite antibiotic therapy, he underwent successful mitral and tricuspid valve replacement. Pathologic analysis of the culture-negative valve specimens were found to contain inclusion bodies consistent with CMV, and quantitative serum polymerase chain reaction returned a highly elevated CMV DNA count.

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AN - SCOPUS:84990194217

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JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

IS - 2

ER -

Valvular Cytomegalovirus Endocarditis

Abstract

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