TY - JOUR
T1 - Validity and Normative Data for the Biber Figure Learning Test
T2 - A Visual Supraspan Memory Measure
AU - Gifford, Katherine A.
AU - Liu, Dandan
AU - Neal, Jacquelyn E.
AU - Acosta, Lealani Mae Y.
AU - Bell, Susan P.
AU - Wiggins, Margaret E.
AU - Wisniewski, Kristi M.
AU - Godfrey, Mary
AU - Logan, Laura A.
AU - Hohman, Timothy J.
AU - Pechman, Kimberly R.
AU - Libon, David J.
AU - Blennow, Kaj
AU - Zetterberg, Henrik
AU - Jefferson, Angela L.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by K24-AG046373 (ALJ); Alzheimer’s Association IIRG-08-88733 (ALJ); R01-AG034962 (ALJ); R01-HL111516 (ALJ); R01-NS100980 (ALJ); R01-AG056534 (ALJ); K12-HD043483 (KAG/TJH/SPB); Alzheimer’s Association NIRG-13-283276 (KAG); K23-AG045966 (KAG); Paul B. Beeson Career Development Award in Aging K23-AG048347 (SPB); the Eisenstein Women’s Heart Fund (SBP); K01-AG049164 (TJH); T32-AG000037 (KMW); UL1-TR000445 (Vanderbilt Institute for Clinical & Translational Research); S10-OD023680 (Vanderbilt’s High-Performance Computer Cluster for Biomedical Research); the Vanderbilt Memory & Alzheimer’s Center; the Swedish Research Council; the Swedish Alzheimer’s Association; and Torsten Söderberg Foundation, Stockholm, Sweden.
Publisher Copyright:
© The Author(s) 2018.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - The Biber Figure Learning Test (BFLT), a visuospatial serial figure learning test, was evaluated for biological correlates and psychometric properties, and normative data were generated. Nondemented individuals (n = 332, 73 ± 7, 41% female) from the Vanderbilt Memory & Aging Project completed a comprehensive neuropsychological protocol. Adjusted regression models related BFLT indices to structural brain magnetic resonance imaging and cerebrospinal fluid (CSF) markers of brain health. Regression-based normative data were generated. Lower BFLT performances (Total Learning, Delayed Recall, Recognition) related to smaller medial temporal lobe volumes and higher CSF tau concentrations but not CSF amyloid. BFLT indices were most strongly correlated with other measures of verbal and nonverbal memory and visuospatial skills. The BFLT provides a comprehensive assessment of all aspects of visuospatial learning and memory and is sensitive to biomarkers of unhealthy brain aging. Enhanced normative data enriches the clinical utility of this visual serial figure learning test for use with older adults.
AB - The Biber Figure Learning Test (BFLT), a visuospatial serial figure learning test, was evaluated for biological correlates and psychometric properties, and normative data were generated. Nondemented individuals (n = 332, 73 ± 7, 41% female) from the Vanderbilt Memory & Aging Project completed a comprehensive neuropsychological protocol. Adjusted regression models related BFLT indices to structural brain magnetic resonance imaging and cerebrospinal fluid (CSF) markers of brain health. Regression-based normative data were generated. Lower BFLT performances (Total Learning, Delayed Recall, Recognition) related to smaller medial temporal lobe volumes and higher CSF tau concentrations but not CSF amyloid. BFLT indices were most strongly correlated with other measures of verbal and nonverbal memory and visuospatial skills. The BFLT provides a comprehensive assessment of all aspects of visuospatial learning and memory and is sensitive to biomarkers of unhealthy brain aging. Enhanced normative data enriches the clinical utility of this visual serial figure learning test for use with older adults.
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U2 - 10.1177/1073191118773870
DO - 10.1177/1073191118773870
M3 - Article
C2 - 29809069
AN - SCOPUS:85047825265
SN - 1073-1911
VL - 27
SP - 1320
EP - 1334
JO - Assessment
JF - Assessment
IS - 6
ER -