Utility of Autoantibodies as Biomarkers for Diagnosis and Staging of Neurodegenerative Diseases

Cassandra DeMarshall, Abhirup Sarkar, Eric P. Nagele, Eric Goldwaser, George Godsey, Nimish K. Acharya, Robert Nagele

Research output: Chapter in Book/Report/Conference proceedingConference contribution

24 Scopus citations

Abstract

Autoantibodies are self-reactive antibodies that have been widely implicated as causal agents of autoimmune diseases. They are found in the blood of all human sera, regardless of age, gender, or the presence or absence of disease. While the underlying reason for their ubiquity remains unknown, it has been hypothesized that they participate in the clearance of blood-borne cell and tissue debris generated in both healthy and diseased individuals on a daily basis. Although much evidence supports this debris clearance role, recent studies also suggest a causal role for autoantibodies in disease. This chapter first presents well-known examples of autoimmune diseases that emphasize a direct causal role for autoantibodies and then discusses the veritable explosion of evidence now supporting their involvement in a wide variety of other diseases, including cancers and several types of neurological and neurodegenerative diseases. Lastly, translational strategies that take advantage of the "cause and/or effect" role of autoantibodies and recent technological advancements in their detection to exploit autoantibodies as sensitive and specific biomarkers useful for the detection and diagnosis of disease are outlined. Their use in the diagnosis and staging of Alzheimer's and Parkinson's diseases is presented, and future applications in clinical medicine and basic science are highlighted.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
Subtitle of host publicationOmic Studies of Neurodegenerative Disease: Part B, 2015
EditorsMichael J. Hurley
PublisherAcademic Press Inc.
Pages1-51
Number of pages51
ISBN (Print)9780128047620
DOIs
StatePublished - Jan 1 2015

Publication series

NameInternational Review of Neurobiology
Volume122
ISSN (Print)0074-7742

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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    DeMarshall, C., Sarkar, A., Nagele, E. P., Goldwaser, E., Godsey, G., Acharya, N. K., & Nagele, R. (2015). Utility of Autoantibodies as Biomarkers for Diagnosis and Staging of Neurodegenerative Diseases. In M. J. Hurley (Ed.), International Review of Neurobiology: Omic Studies of Neurodegenerative Disease: Part B, 2015 (pp. 1-51). (International Review of Neurobiology; Vol. 122). Academic Press Inc.. https://doi.org/10.1016/bs.irn.2015.05.005