Using benzoyl chloride derivatization to improve small-molecule analysis in biological samples by LC-MS/MS

James P. Grinias, Jenny Marie T. Wong, Kathryn M. Nesbitt

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this article, we describe the process of sample preparation and method development for the analysis of polar small molecules using benzoyl chloride (BzCl) derivatization and liquid chromatography-tandem mass spectrometry (LC-MS/MS). We also highlight several recent applications of these techniques to metabolomics analyses.

Original languageEnglish (US)
Pages (from-to)760-768
Number of pages9
JournalLC-GC North America
Volume35
Issue number10
StatePublished - Oct 2017

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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