Using benzoyl chloride derivatization to improve small-molecule analysis in biological samples by LC-MS/MS

James P. Grinias; Jenny Marie T. Wong; Kathryn M. Nesbitt

Using benzoyl chloride derivatization to improve small-molecule analysis in biological samples by LC-MS/MS

James P. Grinias, Jenny Marie T. Wong, Kathryn M. Nesbitt

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In this article, we describe the process of sample preparation and method development for the analysis of polar small molecules using benzoyl chloride (BzCl) derivatization and liquid chromatography-tandem mass spectrometry (LC-MS/MS). We also highlight several recent applications of these techniques to metabolomics analyses.

Original language	English (US)
Pages (from-to)	760-768
Number of pages	9
Journal	LC-GC North America
Volume	35
Issue number	10
State	Published - Oct 2017

All Science Journal Classification (ASJC) codes

Analytical Chemistry

Cite this

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title = "Using benzoyl chloride derivatization to improve small-molecule analysis in biological samples by LC-MS/MS",

abstract = "In this article, we describe the process of sample preparation and method development for the analysis of polar small molecules using benzoyl chloride (BzCl) derivatization and liquid chromatography-tandem mass spectrometry (LC-MS/MS). We also highlight several recent applications of these techniques to metabolomics analyses.",

author = "Grinias, {James P.} and Wong, {Jenny Marie T.} and Nesbitt, {Kathryn M.}",

year = "2017",

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journal = "LC-GC North America",

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T1 - Using benzoyl chloride derivatization to improve small-molecule analysis in biological samples by LC-MS/MS

AU - Grinias, James P.

AU - Wong, Jenny Marie T.

AU - Nesbitt, Kathryn M.

PY - 2017/10

Y1 - 2017/10

N2 - In this article, we describe the process of sample preparation and method development for the analysis of polar small molecules using benzoyl chloride (BzCl) derivatization and liquid chromatography-tandem mass spectrometry (LC-MS/MS). We also highlight several recent applications of these techniques to metabolomics analyses.

AB - In this article, we describe the process of sample preparation and method development for the analysis of polar small molecules using benzoyl chloride (BzCl) derivatization and liquid chromatography-tandem mass spectrometry (LC-MS/MS). We also highlight several recent applications of these techniques to metabolomics analyses.

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SN - 1527-5949

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JO - LC-GC North America

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IS - 10

ER -

Using benzoyl chloride derivatization to improve small-molecule analysis in biological samples by LC-MS/MS

Abstract

All Science Journal Classification (ASJC) codes

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