Using a nanopore for single molecule detection and single cell transfection

Edward M. Nelson, Volker Kurz, Jiwook Shim, Winston Timp, Gregory Timp

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


We assert that it is possible to trap and identify proteins, and even (conceivably) manipulate proteins secreted from a single cell (i.e. the secretome) through transfection via electroporation by exploiting the exquisite control over the electrostatic potential available in a nanopore. These capabilities may be leveraged for single cell analysis and transfection with single molecule resolution, ultimately enabling a careful scrutiny of tissue heterogeneity.

Original languageEnglish (US)
Pages (from-to)3020-3027
Number of pages8
Issue number13
StatePublished - Jul 7 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry


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