We assert that it is possible to trap and identify proteins, and even (conceivably) manipulate proteins secreted from a single cell (i.e. the secretome) through transfection via electroporation by exploiting the exquisite control over the electrostatic potential available in a nanopore. These capabilities may be leveraged for single cell analysis and transfection with single molecule resolution, ultimately enabling a careful scrutiny of tissue heterogeneity.
|Original language||English (US)|
|Number of pages||8|
|State||Published - Jul 7 2012|
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Environmental Chemistry