Abstract
We assert that it is possible to trap and identify proteins, and even (conceivably) manipulate proteins secreted from a single cell (i.e. the secretome) through transfection via electroporation by exploiting the exquisite control over the electrostatic potential available in a nanopore. These capabilities may be leveraged for single cell analysis and transfection with single molecule resolution, ultimately enabling a careful scrutiny of tissue heterogeneity.
Original language | English (US) |
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Pages (from-to) | 3020-3027 |
Number of pages | 8 |
Journal | Analyst |
Volume | 137 |
Issue number | 13 |
DOIs | |
State | Published - Jul 7 2012 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biochemistry
- Environmental Chemistry
- Spectroscopy
- Electrochemistry