Understanding HSV-I entry glycoproteins

Adi Reske, Gabriele Pollara, Claude Krummenacher, Benjamin M. Chain, David R. Katz

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations

Abstract

Herpes Simplex Virus-1 is a common infectious agent, but the precise detail of entry and infection of cells has only now begun to be clarified. Four viral surface glycoproteins (gB, gD, gH and gL) are required. This review summarises the known structure and function of each of these essential viral envelope glycoproteins, and explores what is known about their close cooperation with each other in mediating cellular membrane fusion. It is suggested that, following gD binding to one of its entry receptors, membrane fusion is mediated by gB and the heterodimer gH/gL. Significantly, these four entry glycoproteins also play a key role in the interaction between HSV and the host immune system. The glycoproteins serve an important role as targets of adaptive immunity. However, recent studies have demonstrated that the same proteins also play a key role in initiating the early innate immune response to HSV. Understanding the complex functions of these HSV proteins may be essential for successful development of vaccines for HSV.

Original languageEnglish (US)
Pages (from-to)205-215
Number of pages11
JournalReviews in Medical Virology
Volume17
Issue number3
DOIs
StatePublished - May 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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