Two C. elegans genes control the programmed deaths of specific cells in the pharynx

Ronald E. Ellis, H. Robert Horvitz

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

The genes ces-1 and ces-2 control the decisions of two cells in the nematode Caenorhabditis elegans to undergo programmed cell death. Mutations that cause a gain of ces-1 function or a reduction of ces-2 function prevent these cells, the sisters of the two pharyngeal NSM neurons, from dying. These mutations do not affect most other cell deaths. Genetic studies indicate that ces-1 and ces-2 affect the fates of the NSM sisters by regulating the genes required for all programmed cell deaths to occur.

Original languageEnglish (US)
Pages (from-to)591-603
Number of pages13
JournalDevelopment
Volume112
Issue number2
StatePublished - Jun 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Two C. elegans genes control the programmed deaths of specific cells in the pharynx'. Together they form a unique fingerprint.

Cite this