Treatment and outcomes of Candida osteomyelitis: Review of 53 cases from the PATH Alliance® registry

D. Neofytos, S. Huprikar, A. Reboli, M. Schuster, N. Azie, B. Franks, D. Horn

    Research output: Contribution to journalArticle

    17 Scopus citations

    Abstract

    Candida osteomyelitis is associated with significant morbidity; however, data on the management of Candida osteomyelitis are limited. The Prospective Antifungal Therapy (PATH) Alliance® registry is a comprehensive, multicenter, prospective, observational registry that collected data on patients with invasive fungal infections between 2004 and 2008. The aim of this descriptive analysis was to evaluate the clinical characteristics, treatment, and outcomes of patients with Candida osteomyelitis. Using the PATH Alliance® registry, we performed a review of all patients with a proven diagnosis of Candida osteomyelitis who received a minimum of 14 days of antifungal treatment and/or a therapeutic surgical intervention (n = 53). The epidemiology, diagnosis, treatment, and outcomes of these patients were assessed at 12 weeks. C. albicans (56.6 %) was the most commonly identified organism, followed by C. parapsilosis (18.9 %), C. glabrata (9.4 %), and C. tropicalis (9.4 %). The mean treatment duration was 54.9 days. Multiple different treatment regimens were administered to patients. These included fluconazole (56.0 %), echinocandins (29.3 %), amphotericin B formulations (10.7 %), and voriconazole (4.0 %). Twenty-eight patients (52.8 %) also had a therapeutic surgical intervention. Clinical response was improved in 38 (71.7 %) patients (43.4 % complete and 28.3 % partial response), stable in 11 (20.8 %), and worse in one (1.9 %); three (5.7 %) patients had unknown response. The 12-week survival rate was 93.8 %. In summary, C. albicans was the predominant pathogen, and fluconazole was the most commonly administered agent. However, treatment patterns vary and remain non-standardized. Concurrent candidemia was infrequent, and 12-week survival was notably good in this series of 53 patients with Candida osteomyelitis.

    Original languageEnglish (US)
    Pages (from-to)135-141
    Number of pages7
    JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
    Volume33
    Issue number1
    DOIs
    StatePublished - Jan 1 2014

    All Science Journal Classification (ASJC) codes

    • Microbiology (medical)
    • Infectious Diseases

    Fingerprint Dive into the research topics of 'Treatment and outcomes of Candida osteomyelitis: Review of 53 cases from the PATH Alliance® registry'. Together they form a unique fingerprint.

  • Cite this