Treating dementia patients with vascular lesions with donepezil: A preliminary analysis

David A. Thomas, David J. Libon, George E. Ledakis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Sixteen patients with Alzheimer's disease (AD) and 15 patients with vascular dementia (VaD) associated with subcortical white matter lesions or subcortical cardiovascular accidents (CVAs) were treated with donepezilfor 16 weeks. Within-group analyses for the AD group revealed significant improvement on some tests of working memory, and marginal improvement on the Mini-Mental State Examination and on tests of immediate free recall from a serial list-learning task. Identical analyses for the VaD group revealed substantial gains on tests of working memory and delayed recognition memory. These data suggest that medication such as donepezil may act to improve the working memory deficits known to be associated with dementia patients with subcortical vascular lesions. The clinical implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalApplied Neuropsychology
Issue number1
StatePublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)


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