Translational apparatus of microorganisms at low temperature

Jihwan Hwang, Masayori Inouye, Sangita Phadtare

Research output: Chapter in Book/Report/Conference proceedingChapter


Temperature up-shift or down-shift is one of the major environmental stresses encountered by microorganisms. Especially, one of the main consequences of temperature down-shift on cells is conformational changes of secondary structures of RNAs. These cold-shock induced structural changes of RNAs have significant effect on the global gene expressions, i) by improper termination of transcription, ii) inefficient RNA degradation, iii) translation of alternatively-structured mRNAs, and iv) biogenesis of ribosome and processing of rRNA. Several cold-shock proteins are produced to counteract these effects and thus allow cold acclimatization of the cell. This chapter describes how specific cold shock proteins modulate the ribosome biogenesis and eventually translation, to ensure effective protein production at low temperature.

Original languageEnglish (US)
Title of host publicationRibosomes
Subtitle of host publicationMolecular Structure, Role in Biological Functions and Implications for Genetic Diseases
PublisherNova Science Publishers, Inc.
Number of pages15
ISBN (Print)9781624176982
StatePublished - Mar 1 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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