Total synthesis of Resolvin D1, a potent anti-inflammatory lipid mediator

Ana R. Rodriguez, Bernd W. Spur

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The total synthesis of Resolvin D1, a potent endogenous anti-inflammatory lipid mediator derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C7, C8 and C17 were obtained via a chiral pool strategy from 2-deoxy-d-ribose. Wittig reactions followed by a modified Pd0/Cu I Sonogashira coupling and Zn(Cu/Ag) cis-reduction completed the total synthesis of Resolvin D1.

Original languageEnglish (US)
Pages (from-to)6990-6994
Number of pages5
JournalTetrahedron Letters
Volume53
Issue number51
DOIs
StatePublished - Dec 19 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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