Total synthesis of lipoxin A4 and lipoxin B4 from butadiene

A. Rodríguez, M. Nomen, B. W. Spur, J. J. Godfroid, T. H. Lee

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The total synthesis of LXA4 and LXB4 has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO2/Cs2CO3 procedure, generated the asymmetric centers. The flexibility of the strategy allows an easy access to the linear eicosanoids. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)823-826
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number6
DOIs
StatePublished - Feb 5 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Total synthesis of lipoxin A4 and lipoxin B4 from butadiene'. Together they form a unique fingerprint.

Cite this