Total synthesis of lipoxin A4 and lipoxin B4 from butadiene

A. Rodríguez; M. Nomen; B. W. Spur; J. J. Godfroid; T. H. Lee

doi:10.1016/S0040-4039(99)02201-7

Total synthesis of lipoxin A₄ and lipoxin B₄ from butadiene

A. Rodríguez, M. Nomen, B. W. Spur, J. J. Godfroid, T. H. Lee

Cell Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The total synthesis of LXA₄ and LXB₄ has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO₂/Cs₂CO₃ procedure, generated the asymmetric centers. The flexibility of the strategy allows an easy access to the linear eicosanoids. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	823-826
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	6
DOIs	https://doi.org/10.1016/S0040-4039(99)02201-7
State	Published - Feb 5 2000

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(99)02201-7

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AU - Rodríguez, A.

AU - Nomen, M.

AU - Spur, B. W.

AU - Godfroid, J. J.

AU - Lee, T. H.

PY - 2000/2/5

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AB - The total synthesis of LXA4 and LXB4 has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO2/Cs2CO3 procedure, generated the asymmetric centers. The flexibility of the strategy allows an easy access to the linear eicosanoids. (C) 2000 Elsevier Science Ltd.

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Total synthesis of lipoxin A₄ and lipoxin B₄ from butadiene

Abstract

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