To dislodge an enzyme from an ion channel, try steroids

Susy C. Kohout; Ehud Y. Isacoff

doi:10.1038/nchembio1108-650

To dislodge an enzyme from an ion channel, try steroids

Susy C. Kohout
, Ehud Y. Isacoff

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Voltage-gated K⁺ channels assemble into complexes with Kvβs, a group of aldoketoreductases. The Kvβs regulate channel gating and localization, and voltage-dependent changes in the channel regulate AKR activity. Pan and colleagues now propose a new type of modulation of this complex. Cortisone disrupts the complex and relieves channel inactivation - which should reduce neuronal excitability.

Original language	English (US)
Pages (from-to)	650-651
Number of pages	2
Journal	Nature Chemical Biology
Volume	4
Issue number	11
DOIs	https://doi.org/10.1038/nchembio1108-650
State	Published - Nov 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/nchembio1108-650

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title = "To dislodge an enzyme from an ion channel, try steroids",

abstract = "Voltage-gated K+ channels assemble into complexes with Kvβs, a group of aldoketoreductases. The Kvβs regulate channel gating and localization, and voltage-dependent changes in the channel regulate AKR activity. Pan and colleagues now propose a new type of modulation of this complex. Cortisone disrupts the complex and relieves channel inactivation - which should reduce neuronal excitability.",

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T1 - To dislodge an enzyme from an ion channel, try steroids

AU - Kohout, Susy C.

AU - Isacoff, Ehud Y.

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N2 - Voltage-gated K+ channels assemble into complexes with Kvβs, a group of aldoketoreductases. The Kvβs regulate channel gating and localization, and voltage-dependent changes in the channel regulate AKR activity. Pan and colleagues now propose a new type of modulation of this complex. Cortisone disrupts the complex and relieves channel inactivation - which should reduce neuronal excitability.

AB - Voltage-gated K+ channels assemble into complexes with Kvβs, a group of aldoketoreductases. The Kvβs regulate channel gating and localization, and voltage-dependent changes in the channel regulate AKR activity. Pan and colleagues now propose a new type of modulation of this complex. Cortisone disrupts the complex and relieves channel inactivation - which should reduce neuronal excitability.

UR - https://www.scopus.com/pages/publications/54249162934

UR - https://www.scopus.com/pages/publications/54249162934#tab=citedBy

U2 - 10.1038/nchembio1108-650

DO - 10.1038/nchembio1108-650

M3 - Short survey

C2 - 18936745

AN - SCOPUS:54249162934

SN - 1552-4450

VL - 4

SP - 650

EP - 651

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 11

ER -

To dislodge an enzyme from an ion channel, try steroids

Abstract

All Science Journal Classification (ASJC) codes

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