To dislodge an enzyme from an ion channel, try steroids

Susy C. Kohout, Ehud Y. Isacoff

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


Voltage-gated K+ channels assemble into complexes with Kvβs, a group of aldoketoreductases. The Kvβs regulate channel gating and localization, and voltage-dependent changes in the channel regulate AKR activity. Pan and colleagues now propose a new type of modulation of this complex. Cortisone disrupts the complex and relieves channel inactivation - which should reduce neuronal excitability.

Original languageEnglish (US)
Pages (from-to)650-651
Number of pages2
JournalNature Chemical Biology
Issue number11
StatePublished - Nov 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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