Titanium-mediated fragment union processes in complex molecule synthesis: Development of a branched reaction pathway of high step economy for the synthesis of complex and diverse polyketides

Lark J. Perez, Glenn C. Micalizio

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We describe a synthetic pathway to structurally complex and diverse polyketides based, in part, on regio- and stereoselective titanium-mediated coupling reactions. The sequences described allow for rapid assembly of polyketide-inspired architecture while providing significant flexibility for the establishment of diverse stereochemical relationships and substitution patterns along the carbon backbone (including stereodefined alkenes and 1,3-dienes, saturated and unsaturated lactones, hemiketals, α,β-unsaturated carbonyls, and spiroketals).

Original languageEnglish (US)
Pages (from-to)627-648
Number of pages22
JournalSynthesis
Issue number4
DOIs
StatePublished - Feb 15 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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