Thermogenic Supplementation and Fat Loss in Resistance-Trained Males: A Randomized Controlled Trial

Featured Application: This study demonstrates that chronic ingestion of a thermogenic supplement in conjunction with a resistance training program can significantly enhance fat loss while maintaining strength gains in trained individuals. These findings may inform the development of targeted supplementation strategies for individuals seeking to optimize fat loss while engaging in resistance training. As interest in weight management and metabolic health grows, thermogenic supplements have gained attention for their potential to enhance caloric expenditure and fat loss. This study aimed to investigate the effects of chronic thermogenic supplement ingestion on body composition and strength outcomes during an 8-week periodized resistance training program. Thirty-four resistance-trained males were randomized into thermogenic supplementation (TS) (n = 18) or placebo (n = 16) groups in a double-blind, placebo-controlled design. Participants consumed thermogenic or placebo capsules daily, with dosage adjusted midway through the intervention. Body composition was assessed using ultrasound-based body fat analysis, and strength was measured via bench press and back squat one-repetition maximum (1-RM) tests. Results indicated that TS experienced significantly greater reductions in fat mass (−0.65 kg vs. 0.12 kg, p = 0.029) and body fat percentage (−0.89% vs. −0.08%, p = 0.039) compared to the placebo. Both groups demonstrated significant and comparable improvements in squat (TS: 16.87 kg, placebo: 18.47 kg) and bench press strength (TS: 7.80 kg, placebo: 7.13 kg). These findings suggest that thermogenic supplement ingestion can enhance fat loss without impeding strength adaptations. Future research should explore the dose–response effects and applicability of thermogenics in different populations and over extended durations.