The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression

Christina Gallo-Ebert; Melissa Donigan; Hsing Yin Liu; Florencia Pascual; Melissa Manners; Devanshi Pandya; Robert Swanson; Denise Gallagher; Weiwei Chen; George M. Carman; Joseph T. Nickels

doi:10.1074/jbc.M113.526087

The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression

Christina Gallo-Ebert
, Melissa Donigan
, Hsing Yin Liu
, Florencia Pascual
, Melissa Manners
, Devanshi Pandya
, Robert Swanson
, Denise Gallagher
, Weiwei Chen
, George M. Carman
, Joseph T. Nickels

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Saccharomyces cerevisiae sterol gene expression is regulated by a consensus sterol-response promoter element (SRE/AR1_c). Results: The anaerobic AR1_b promoter element regulates global antifungal-dependent sterol gene expression. Conclusion: Yeast sterol gene expression is regulated by multiple SRE-like elements. Significance: Understanding sterol gene expression will yield valuable information concerning antifungal drug resistance.

Original language	English (US)
Pages (from-to)	35466-35477
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	49
DOIs	https://doi.org/10.1074/jbc.M113.526087
State	Published - Dec 6 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.526087

Cite this

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title = "The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression",

abstract = "Background: Saccharomyces cerevisiae sterol gene expression is regulated by a consensus sterol-response promoter element (SRE/AR1c). Results: The anaerobic AR1b promoter element regulates global antifungal-dependent sterol gene expression. Conclusion: Yeast sterol gene expression is regulated by multiple SRE-like elements. Significance: Understanding sterol gene expression will yield valuable information concerning antifungal drug resistance.",

author = "Christina Gallo-Ebert and Melissa Donigan and Liu, \{Hsing Yin\} and Florencia Pascual and Melissa Manners and Devanshi Pandya and Robert Swanson and Denise Gallagher and Weiwei Chen and Carman, \{George M.\} and Nickels, \{Joseph T.\}",

year = "2013",

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day = "6",

doi = "10.1074/jbc.M113.526087",

language = "English (US)",

volume = "288",

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TY - JOUR

T1 - The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression

AU - Gallo-Ebert, Christina

AU - Donigan, Melissa

AU - Liu, Hsing Yin

AU - Pascual, Florencia

AU - Manners, Melissa

AU - Pandya, Devanshi

AU - Swanson, Robert

AU - Gallagher, Denise

AU - Chen, Weiwei

AU - Carman, George M.

AU - Nickels, Joseph T.

PY - 2013/12/6

Y1 - 2013/12/6

N2 - Background: Saccharomyces cerevisiae sterol gene expression is regulated by a consensus sterol-response promoter element (SRE/AR1c). Results: The anaerobic AR1b promoter element regulates global antifungal-dependent sterol gene expression. Conclusion: Yeast sterol gene expression is regulated by multiple SRE-like elements. Significance: Understanding sterol gene expression will yield valuable information concerning antifungal drug resistance.

AB - Background: Saccharomyces cerevisiae sterol gene expression is regulated by a consensus sterol-response promoter element (SRE/AR1c). Results: The anaerobic AR1b promoter element regulates global antifungal-dependent sterol gene expression. Conclusion: Yeast sterol gene expression is regulated by multiple SRE-like elements. Significance: Understanding sterol gene expression will yield valuable information concerning antifungal drug resistance.

UR - https://www.scopus.com/pages/publications/84890287132

UR - https://www.scopus.com/pages/publications/84890287132#tab=citedBy

U2 - 10.1074/jbc.M113.526087

DO - 10.1074/jbc.M113.526087

M3 - Article

C2 - 24163365

AN - SCOPUS:84890287132

SN - 0021-9258

VL - 288

SP - 35466

EP - 35477

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 49

ER -

The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression

Abstract

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