The Sperm/Oocyte Decision, a C. elegans Perspective

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The decision of germ cells to differentiate into spermatocytes or oocytes is one of the most complex choices in development, but it is made long before later changes in cell morphology, and its mechanisms remain elusive. Because of the advantages of hermaphrodite genetics, the nematode C. elegans has become a model for this process. In worms, the core sex-determination pathway controls sexual fates throughout the body, and acts through the transcription factor TRA-1 to regulate fog-1 and fog-3, which specify spermatogenesis and prevent oogenesis. Furthermore, the activities of key genes in this pathway are modulated in the germ line to allow hermaphroditic development, so that XX animals produce a small number of sperm. Many of these modulators work by controlling the translation of target messenger RNAs. Translational regulators play a major role in many aspects of germ cell fate, since some of them prevent maternal transcripts from influencing the sperm/oocyte decision, and some regulate essential transcripts in the germ line and early embryo. In fact, the expression patterns set up by interactions among these translational regulators, acting in concert with signals from the somatic gonad, can explain how germ cell fates are specified.

Original languageEnglish (US)
Title of host publicationOogenesis
Subtitle of host publicationThe Universal Process
PublisherJohn Wiley and Sons
Pages1-26
Number of pages26
ISBN (Print)9780470696828
DOIs
StatePublished - Apr 21 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

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