The role of extracellular material in chick neurulation. I. Effects of concanavalin A

Hsin‐Yi ‐Y Lee, Joel B. Sheffield, Robert Nagele, Gerhard W. Kalmus

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29 Scopus citations

Abstract

The distribution of extracellular material (ECM) in developing neuroepithelium of stage 8+ chick embryos was investigated using lanthanum nitrate. The temporal changes in the distribution of ECM was correlated with the ongoing morphogenetic movements. The most striking finding was that as the folds were about to meet, thick dense ECM appeared between leading edges. Concanavalin A inhibited neural tube closure by binding to cell surfaces and disrupting the usual distribution of ECM in developing neuroepithelium.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalJournal of Experimental Zoology
Volume198
Issue number2
DOIs
StatePublished - Jan 1 1976

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

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