The role of extracellular material in chick neurulation. I. Effects of concanavalin A

Hsin‐Yi ‐Y Lee; Joel B. Sheffield; Robert G. Nagele; Gerhard W. Kalmus

doi:10.1002/jez.1401980216

The role of extracellular material in chick neurulation. I. Effects of concanavalin A

Hsin‐Yi ‐Y Lee, Joel B. Sheffield, Robert G. Nagele, Gerhard W. Kalmus

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Abstract

The distribution of extracellular material (ECM) in developing neuroepithelium of stage 8₊ chick embryos was investigated using lanthanum nitrate. The temporal changes in the distribution of ECM was correlated with the ongoing morphogenetic movements. The most striking finding was that as the folds were about to meet, thick dense ECM appeared between leading edges. Concanavalin A inhibited neural tube closure by binding to cell surfaces and disrupting the usual distribution of ECM in developing neuroepithelium.

Original language	English (US)
Pages (from-to)	261-266
Number of pages	6
Journal	Journal of Experimental Zoology
Volume	198
Issue number	2
DOIs	https://doi.org/10.1002/jez.1401980216
State	Published - Nov 1976
Externally published	Yes

All Science Journal Classification (ASJC) codes

Animal Science and Zoology

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10.1002/jez.1401980216

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abstract = "The distribution of extracellular material (ECM) in developing neuroepithelium of stage 8+ chick embryos was investigated using lanthanum nitrate. The temporal changes in the distribution of ECM was correlated with the ongoing morphogenetic movements. The most striking finding was that as the folds were about to meet, thick dense ECM appeared between leading edges. Concanavalin A inhibited neural tube closure by binding to cell surfaces and disrupting the usual distribution of ECM in developing neuroepithelium.",

author = "Lee, {Hsin‐Yi ‐Y} and Sheffield, {Joel B.} and Nagele, {Robert G.} and Kalmus, {Gerhard W.}",

year = "1976",

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AU - Kalmus, Gerhard W.

PY - 1976/11

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AB - The distribution of extracellular material (ECM) in developing neuroepithelium of stage 8+ chick embryos was investigated using lanthanum nitrate. The temporal changes in the distribution of ECM was correlated with the ongoing morphogenetic movements. The most striking finding was that as the folds were about to meet, thick dense ECM appeared between leading edges. Concanavalin A inhibited neural tube closure by binding to cell surfaces and disrupting the usual distribution of ECM in developing neuroepithelium.

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The role of extracellular material in chick neurulation. I. Effects of concanavalin A

Abstract

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