The major centromeric array of alphoid satellite DNA on the human Y chromosome is non-palindromic

Katrina F. Cooper, Richard B. Fisher, Chris Tyler-smith

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We have determined the orientation of the major centromeric alphoid array on the human Y chromosome. A PCR assay was used to analyse the vector-insert junctions of seven YAC clones previously positioned on two independent Y chromosomes. The orientation is the same at all 10 positions measured. This suggests that the alphoid array is a simple unidirectional repeat throughout and that human centromere structure thus differs from the palindromic organisation found in Schizosaccharomyces pombe.

Original languageEnglish (US)
Pages (from-to)1267-1270
Number of pages4
JournalHuman molecular genetics
Volume2
Issue number8
DOIs
StatePublished - Aug 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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