The locus coeruleus-norepinephrine system and sensory signal processing: A historical review and current perspectives

Barry Waterhouse, Rachel L. Navarra

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Many studies in intact animals have shown that locally applied or synaptically released norepinephrine (NE) can enhance individual neuron and neural network responses to sensory inputs. However, a major unanswered question is how and when noradrenergically-mediated changes in sensory signal processing can influence downstream decision making, motor responding, and ultimately behavioral outcomes. Recent work using a variety of approaches in different sensory networks has started to consider this question. Evidence collected to date as reported in this Special Edition of Brain Research suggests that output from the brainstem locus coeruleus (LC)-NE system can modify task-related sensory signal processing and by so doing influence goal-directed behavioral responding. This report reviews the work leading to this most recent line of inquiry and at the same time identifies areas for future investigation.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalBrain Research
Volume1709
DOIs
StatePublished - Apr 15 2019

Fingerprint

Locus Coeruleus
Norepinephrine
Brain Stem
Decision Making
Neurons
Brain
Research

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

@article{6cdbdb5922dd49bbbde851af67a082bc,
title = "The locus coeruleus-norepinephrine system and sensory signal processing: A historical review and current perspectives",
abstract = "Many studies in intact animals have shown that locally applied or synaptically released norepinephrine (NE) can enhance individual neuron and neural network responses to sensory inputs. However, a major unanswered question is how and when noradrenergically-mediated changes in sensory signal processing can influence downstream decision making, motor responding, and ultimately behavioral outcomes. Recent work using a variety of approaches in different sensory networks has started to consider this question. Evidence collected to date as reported in this Special Edition of Brain Research suggests that output from the brainstem locus coeruleus (LC)-NE system can modify task-related sensory signal processing and by so doing influence goal-directed behavioral responding. This report reviews the work leading to this most recent line of inquiry and at the same time identifies areas for future investigation.",
author = "Barry Waterhouse and Navarra, {Rachel L.}",
year = "2019",
month = "4",
day = "15",
doi = "10.1016/j.brainres.2018.08.032",
language = "English (US)",
volume = "1709",
pages = "1--15",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

The locus coeruleus-norepinephrine system and sensory signal processing : A historical review and current perspectives. / Waterhouse, Barry; Navarra, Rachel L.

In: Brain Research, Vol. 1709, 15.04.2019, p. 1-15.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The locus coeruleus-norepinephrine system and sensory signal processing

T2 - A historical review and current perspectives

AU - Waterhouse, Barry

AU - Navarra, Rachel L.

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Many studies in intact animals have shown that locally applied or synaptically released norepinephrine (NE) can enhance individual neuron and neural network responses to sensory inputs. However, a major unanswered question is how and when noradrenergically-mediated changes in sensory signal processing can influence downstream decision making, motor responding, and ultimately behavioral outcomes. Recent work using a variety of approaches in different sensory networks has started to consider this question. Evidence collected to date as reported in this Special Edition of Brain Research suggests that output from the brainstem locus coeruleus (LC)-NE system can modify task-related sensory signal processing and by so doing influence goal-directed behavioral responding. This report reviews the work leading to this most recent line of inquiry and at the same time identifies areas for future investigation.

AB - Many studies in intact animals have shown that locally applied or synaptically released norepinephrine (NE) can enhance individual neuron and neural network responses to sensory inputs. However, a major unanswered question is how and when noradrenergically-mediated changes in sensory signal processing can influence downstream decision making, motor responding, and ultimately behavioral outcomes. Recent work using a variety of approaches in different sensory networks has started to consider this question. Evidence collected to date as reported in this Special Edition of Brain Research suggests that output from the brainstem locus coeruleus (LC)-NE system can modify task-related sensory signal processing and by so doing influence goal-directed behavioral responding. This report reviews the work leading to this most recent line of inquiry and at the same time identifies areas for future investigation.

UR - http://www.scopus.com/inward/record.url?scp=85053613049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053613049&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2018.08.032

DO - 10.1016/j.brainres.2018.08.032

M3 - Review article

C2 - 30179606

AN - SCOPUS:85053613049

VL - 1709

SP - 1

EP - 15

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -