The locus coeruleus-noradrenergic system: Modulation of behavioral state and state-dependent cognitive processes

Craig W. Berridge, Barry Waterhouse

Research output: Contribution to journalReview article

1418 Citations (Scopus)

Abstract

Through a widespread efferent projection system, the locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system. Initial studies provided critical insight into the basic organization and properties of this system. More recent work identifies a complicated array of behavioral and electrophysiological actions that have in common the facilitation of processing of relevant, or salient, information. This involves two basic levels of action. First, the system contributes to the initiation and maintenance of behavioral and forebrain neuronal activity states appropriate for the collection of sensory information (e.g. waking). Second, within the waking state, this system modulates the collection and processing of salient sensory information through a diversity of concentration-dependent actions within cortical and subcortical sensory, attention, and memory circuits. Norepinephrine-dependent modulation of long-term alterations in synaptic strength, gene transcription and other processes suggest a potentially critical role of this neurotransmitter system in experience-dependent alterations in neural function and behavior. The ability of a given stimulus to increase locus coeruleus discharge activity appears independent of affective valence (appetitive vs. aversive). Combined, these observations suggest that the locus coeruleus-noradrenergic system is a critical component of the neural architecture supporting interaction with, and navigation through, a complex world. These observations further suggest that dysregulation of locus coeruleus-noradrenergic neurotransmission may contribute to cognitive and/or arousal dysfunction associated with a variety of psychiatric disorders, including attention-deficit hyperactivity disorder, sleep and arousal disorders, as well as certain affective disorders, including post-traumatic stress disorder. Independent of an etiological role in these disorders, the locus coeruleus-noradrenergic system represents an appropriate target for pharmacological treatment of specific attention, memory and/or arousal dysfunction associated with a variety of behavioral/cognitive disorders.

Original languageEnglish (US)
Pages (from-to)33-84
Number of pages52
JournalBrain Research Reviews
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Locus Coeruleus
Arousal
Sleep Arousal Disorders
Norepinephrine
Aptitude
Attention Deficit Disorder with Hyperactivity
Post-Traumatic Stress Disorders
Prosencephalon
Mood Disorders
Synaptic Transmission
Neurotransmitter Agents
Psychiatry
Central Nervous System
Maintenance
Pharmacology
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

Cite this

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The locus coeruleus-noradrenergic system : Modulation of behavioral state and state-dependent cognitive processes. / Berridge, Craig W.; Waterhouse, Barry.

In: Brain Research Reviews, Vol. 42, No. 1, 01.01.2003, p. 33-84.

Research output: Contribution to journalReview article

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