The impact of overweight/obesity duration and physical activity on telomere length: An application of the WATCH paradigm

Scott J Dankel, Jeremy P Loenneke, Paul D Loprinzi

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations

    Abstract

    INTRODUCTION: Physical activity may protect against health consequences associated with obesity, yet less is known on how the duration of obesity alters this association, specifically as it relates to leukocyte telomere length.

    METHODS: The 1999-2002 NHANES was used to place individuals into 6 mutually exclusive groups based on physical activity status and weight status/duration.

    RESULTS: All active individuals, except for those overweight/obese for longer durations, were associated with longer telomeres in comparison to sedentary individuals.

    CONCLUSIONS: Physical activity may attenuate the decline in telomere length associated with obesity, but this protective effect may be negated by prolonged periods of overweight/obesity.

    Original languageEnglish (US)
    Pages (from-to)247-252
    Number of pages6
    JournalObesity Research and Clinical Practice
    Volume11
    Issue number2
    DOIs
    StatePublished - Nov 28 2016

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