The Immune Response to Exercise: Effects on Cellular Mobilization, Immune Function and Muscle Regeneration

Daniel J. Freidenreich, Jeff S. Volek

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


This chapter aims to summarize changes in leukocyte mobilization, immune function and leukocyte infiltration after endurance and resistance exercise. The majority of leukocytes are not in the circulation but reside in a reservoir known as the marginated pool. Exercise, through increases in catecholamines and cortisol, stimulates the release of leukocytes from the marginated pool, increasing the number of circulating cells post exercise. Exercise also modifies immune functions such as proliferation, cytotoxicity, phagocytosis and chemotaxis. An important purpose for increasing circulating cells is to provide support for regeneration and repair of muscle tissue after exercise to existing intramuscular leukocytes. One factor that appears to have an important role in the degree and duration of leukocyte infiltration into muscle tissue is the extent of muscle damage. However, many gaps remain in respect to exercise-induced leukocyte mobilization and function, due to different approaches in study design, highlighting areas for future research.

Original languageEnglish (US)
Title of host publicationNutrition and Enhanced Sports Performance
Subtitle of host publicationMuscle Building, Endurance, and Strength
PublisherElsevier Inc.
Number of pages7
ISBN (Print)9780123964540
StatePublished - Aug 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


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