The effect of fluoride contents in fluoridated hydroxyapatite on osteoblast behavior

Haibo Qu; Mei Wei

doi:10.1016/j.actbio.2005.09.003

The effect of fluoride contents in fluoridated hydroxyapatite on osteoblast behavior

Haibo Qu, Mei Wei

Research output: Contribution to journal › Article › peer-review

163 Scopus citations

Abstract

Fluoridated hydroxyapatite (FHA) discs with various fluoride contents (0-0.0577 mol F^-/mol apatite) have been used to investigate the effect of fluoride content on osteoblastic cell behavior. SAOS-3 rat osteosarcoma cells were cultured on FHA discs for different time periods. The cell behavior was examined in terms of cell attachment, proliferation, morphology and differentiation. The fluoride content in FHA discs strongly affected the cell activities. More cell attachment and proliferation were observed on the fluoride-containing FHA discs than on pure hydroxyapatite (HA). The fluoride content also affected the differentiation behavior of osteoblastic cells. Cells on FHA discs demonstrated a higher alkaline phosphatase (ALP) activity than those on pure HA after 3 weeks of culturing. These results suggested that fluoride ions have a significant impact on different osteoblastic cell activities.

Original language	English (US)
Pages (from-to)	113-119
Number of pages	7
Journal	Acta Biomaterialia
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.actbio.2005.09.003
State	Published - Jan 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Biology

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10.1016/j.actbio.2005.09.003

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title = "The effect of fluoride contents in fluoridated hydroxyapatite on osteoblast behavior",

abstract = "Fluoridated hydroxyapatite (FHA) discs with various fluoride contents (0-0.0577 mol F-/mol apatite) have been used to investigate the effect of fluoride content on osteoblastic cell behavior. SAOS-3 rat osteosarcoma cells were cultured on FHA discs for different time periods. The cell behavior was examined in terms of cell attachment, proliferation, morphology and differentiation. The fluoride content in FHA discs strongly affected the cell activities. More cell attachment and proliferation were observed on the fluoride-containing FHA discs than on pure hydroxyapatite (HA). The fluoride content also affected the differentiation behavior of osteoblastic cells. Cells on FHA discs demonstrated a higher alkaline phosphatase (ALP) activity than those on pure HA after 3 weeks of culturing. These results suggested that fluoride ions have a significant impact on different osteoblastic cell activities.",

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AU - Wei, Mei

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AB - Fluoridated hydroxyapatite (FHA) discs with various fluoride contents (0-0.0577 mol F-/mol apatite) have been used to investigate the effect of fluoride content on osteoblastic cell behavior. SAOS-3 rat osteosarcoma cells were cultured on FHA discs for different time periods. The cell behavior was examined in terms of cell attachment, proliferation, morphology and differentiation. The fluoride content in FHA discs strongly affected the cell activities. More cell attachment and proliferation were observed on the fluoride-containing FHA discs than on pure hydroxyapatite (HA). The fluoride content also affected the differentiation behavior of osteoblastic cells. Cells on FHA discs demonstrated a higher alkaline phosphatase (ALP) activity than those on pure HA after 3 weeks of culturing. These results suggested that fluoride ions have a significant impact on different osteoblastic cell activities.

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The effect of fluoride contents in fluoridated hydroxyapatite on osteoblast behavior

Abstract

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