The design and evaluation of heparin-binding foldamers

Sungwook Choi, Dylan J. Clements, Vojislava Pophristic, Ivaylo Ivanov, Satyavani Vemparala, Joel S. Bennett, Michael L. Klein, Jeffrey D. Winkler, William F. DeGrado

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Controlling blood loss: The synthesis of a series of arylamide oligomers 1, which interact with heparin is described. The heparin-small molecule interaction inhibits the heparin's ability to activate antithrombin. These arylamide oligomers are the first example of low-molecular-weight antagonists that inhibit the anticoagulant function of heparin. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)6685-6689
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number41
StatePublished - Oct 21 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry


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