The design and evaluation of heparin-binding foldamers

Sungwook Choi, Dylan J. Clements, Vojislava Pophristic, Ivaylo Ivanov, Satyavani Vemparala, Joel S. Bennett, Michael L. Klein, Jeffrey D. Winkler, William F. DeGrado

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Controlling blood loss: The synthesis of a series of arylamide oligomers 1, which interact with heparin is described. The heparin-small molecule interaction inhibits the heparin's ability to activate antithrombin. These arylamide oligomers are the first example of low-molecular-weight antagonists that inhibit the anticoagulant function of heparin. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)6685-6689
Number of pages5
JournalAngewandte Chemie - International Edition
Volume44
Issue number41
DOIs
StatePublished - Oct 21 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry

Fingerprint

Dive into the research topics of 'The design and evaluation of heparin-binding foldamers'. Together they form a unique fingerprint.

Cite this