TY - JOUR
T1 - The association of polysomnographic sleep on posttraumatic stress disorder symptom clusters in trauma-exposed civilians and veterans
AU - Brownlow, Janeese A.
AU - Miller, Katherine E.
AU - Ross, Richard J.
AU - Barilla, Holly
AU - Kling, Mitchel A.
AU - Bhatnagar, Seema
AU - Mellman, Thomas A.
AU - Gehrman, Philip R.
N1 - Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press on behalf of Sleep Research Society.
PY - 2022
Y1 - 2022
N2 - Study Objectives: Self-reported sleep disturbance has been established as a risk factor and predictor for posttraumatic stress disorder (PTSD); however, less is known about the relationship between objective sleep and PTSD symptom clusters, and the specific role of hyperarousal. The present study examined the relationships between sleep continuity and architecture on PTSD symptom clusters. Methods: Participants underwent two in-laboratory sleep studies to assess sleep continuity and architecture. They also completed the Clinician-Administered PTSD-IV scale and the Structured Clinical Interview for the DSM-IV to assess for PTSD diagnosis and other psychiatric disorders. Results: Sleep continuity (i.e.Total sleep time, sleep efficiency percent, wake after sleep onset, sleep latency) was significantly related to PTSD Cluster B (reexperiencing) symptom severity (R2 =. 27, p <. 001). Sleep architecture, specifically Stage N1 sleep, was significantly associated with PTSD Cluster B (t = 2.98, p =. 004), C (Avoidance; t = 3.11, p =. 003), and D (Hyperarosual; t = 3.79, p <. 001) symptom severity independently of Stages N2, N3, and REM sleep. REM sleep variables (i.e. REM latency, number of REM periods) significantly predicted Cluster D symptoms (R2 =. 17, p =. 002). Conclusions: These data provide evidence for a relationship between objective sleep and PTSD clusters, showing that processes active during Stage N1 sleep may contribute to PTSD symptomatology in civilians and veterans. Further, these data suggest that arousal mechanisms active during REM sleep may also contribute to PTSD hyperarousal symptoms. This paper is part of the War, Trauma, and Sleep Across the Lifespan Collection. This collection is sponsored by the Sleep Research Society.
AB - Study Objectives: Self-reported sleep disturbance has been established as a risk factor and predictor for posttraumatic stress disorder (PTSD); however, less is known about the relationship between objective sleep and PTSD symptom clusters, and the specific role of hyperarousal. The present study examined the relationships between sleep continuity and architecture on PTSD symptom clusters. Methods: Participants underwent two in-laboratory sleep studies to assess sleep continuity and architecture. They also completed the Clinician-Administered PTSD-IV scale and the Structured Clinical Interview for the DSM-IV to assess for PTSD diagnosis and other psychiatric disorders. Results: Sleep continuity (i.e.Total sleep time, sleep efficiency percent, wake after sleep onset, sleep latency) was significantly related to PTSD Cluster B (reexperiencing) symptom severity (R2 =. 27, p <. 001). Sleep architecture, specifically Stage N1 sleep, was significantly associated with PTSD Cluster B (t = 2.98, p =. 004), C (Avoidance; t = 3.11, p =. 003), and D (Hyperarosual; t = 3.79, p <. 001) symptom severity independently of Stages N2, N3, and REM sleep. REM sleep variables (i.e. REM latency, number of REM periods) significantly predicted Cluster D symptoms (R2 =. 17, p =. 002). Conclusions: These data provide evidence for a relationship between objective sleep and PTSD clusters, showing that processes active during Stage N1 sleep may contribute to PTSD symptomatology in civilians and veterans. Further, these data suggest that arousal mechanisms active during REM sleep may also contribute to PTSD hyperarousal symptoms. This paper is part of the War, Trauma, and Sleep Across the Lifespan Collection. This collection is sponsored by the Sleep Research Society.
UR - http://www.scopus.com/inward/record.url?scp=85148504459&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85148504459&partnerID=8YFLogxK
U2 - 10.1093/sleepadvances/zpac024
DO - 10.1093/sleepadvances/zpac024
M3 - Article
AN - SCOPUS:85148504459
SN - 2632-5012
VL - 3
JO - SLEEP Advances
JF - SLEEP Advances
IS - 1
M1 - zpac024
ER -