TY - JOUR
T1 - Temporal order memory differences in Alzheimer's disease and vascular dementia
AU - Hampstead, Benjamin M.
AU - Libon, David J.
AU - Moelter, Stephen T.
AU - Swirsky-Sacchetti, Thomas
AU - Scheffer, Ludo
AU - Platek, Steven M.
AU - Chute, Douglas
N1 - Funding Information:
This material is based upon work done in partial fulfillment of the requirements for Doctor of Philosophy in Clinical Psychology from Drexel University. Subsequent research time was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, and Rehabilitation Research and Development Service through Grants B4602H & B6366W to B.H. The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States Government. Portions of this work were presented at the 2005 annual meetings of the National Academy of Neuropsychology. There are no financial or other conflicts of interest affecting this manuscript. Individuals interested in obtaining a copy of the Letter Sequencing Test may contact the corresponding author.
PY - 2010/7
Y1 - 2010/7
N2 - Determining the order of events is essential for accurate memory recollection: an ability previously linked to both frontal and medial temporal functioning. Frontal-subcortical and medial temporal dysfunction typify vascular dementia (VaD) and Alzheimer's disease (AD), respectively. Therefore, we assessed patients' ordering abilities using a novel sequencing task that progressively increased memory load. VaD patients made more errors and selected more previously encountered stimuli than did AD. Curve analysis revealed a general decline in ordering for VaD whereas error production in AD is more dependent on memory load. These findings generally support the role of frontal-subcortical functioning in temporal order memory.
AB - Determining the order of events is essential for accurate memory recollection: an ability previously linked to both frontal and medial temporal functioning. Frontal-subcortical and medial temporal dysfunction typify vascular dementia (VaD) and Alzheimer's disease (AD), respectively. Therefore, we assessed patients' ordering abilities using a novel sequencing task that progressively increased memory load. VaD patients made more errors and selected more previously encountered stimuli than did AD. Curve analysis revealed a general decline in ordering for VaD whereas error production in AD is more dependent on memory load. These findings generally support the role of frontal-subcortical functioning in temporal order memory.
UR - http://www.scopus.com/inward/record.url?scp=77954403926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954403926&partnerID=8YFLogxK
U2 - 10.1080/13803390903418918
DO - 10.1080/13803390903418918
M3 - Article
C2 - 20087810
AN - SCOPUS:77954403926
SN - 1380-3395
VL - 32
SP - 645
EP - 654
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 6
ER -