Temporal order memory differences in Alzheimer's disease and vascular dementia

Benjamin M. Hampstead, David J. Libon, Stephen T. Moelter, Thomas Swirsky-Sacchetti, Ludo Scheffer, Steven M. Platek, Douglas Chute

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Determining the order of events is essential for accurate memory recollection: an ability previously linked to both frontal and medial temporal functioning. Frontal-subcortical and medial temporal dysfunction typify vascular dementia (VaD) and Alzheimer's disease (AD), respectively. Therefore, we assessed patients' ordering abilities using a novel sequencing task that progressively increased memory load. VaD patients made more errors and selected more previously encountered stimuli than did AD. Curve analysis revealed a general decline in ordering for VaD whereas error production in AD is more dependent on memory load. These findings generally support the role of frontal-subcortical functioning in temporal order memory.

Original languageEnglish (US)
Pages (from-to)645-654
Number of pages10
JournalJournal of Clinical and Experimental Neuropsychology
Issue number6
StatePublished - Jul 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Neurology
  • Clinical Neurology


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