Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents

Ling Zhong, Wanlin Zhang, Claude Krummenacher, Yixin Chen, Qingbing Zheng, Qinjian Zhao, Mu Sheng Zeng, Ningshao Xia, Yi Xin Zeng, Miao Xu, Xiao Zhang

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Herpesviruses are among the most successful viruses found in human populations. They establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry process of herpesviruses into specific target cells requires a well-orchestrated teamwork involving multiple envelope glycoproteins. The conserved glycoprotein B (gB) is the membrane fusogen, of which conformational changes are induced by an entry complex (EC) consisting of at least gH and gL. Despite the high prevalence and heavy disease burdens associated with human herpesviruses (HHVs), vaccines against these pathogens are still lacking, except for varicella zoster virus (VZV). Recent advances in understanding the coordinated mechanisms of action of the key EC glycoproteins and fusogen will help to improve approaches for effective vaccine development and neutralizing antibody (nAb) screening.

Original languageEnglish (US)
Pages (from-to)788-804
Number of pages17
JournalTrends in Microbiology
Volume31
Issue number8
DOIs
StatePublished - Aug 2023

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Virology
  • Microbiology

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