Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters

Ian J. Bakanas; Gustavo Moura

doi:10.1002/ejoc.201601093

Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters

Ian J. Bakanas, Gustavo Moura

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted β-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.

Original language	English (US)
Pages (from-to)	5345-5349
Number of pages	5
Journal	European Journal of Organic Chemistry
Volume	2016
Issue number	32
DOIs	https://doi.org/10.1002/ejoc.201601093
State	Published - Jan 1 2016

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Organic Chemistry

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AB - Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted β-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.

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