TY - JOUR
T1 - Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters
AU - Bakanas, Ian J.
AU - Moura-Letts, Gustavo
N1 - Funding Information:
The donors of the American Chemical Society Petroleum Research Fund financially supported these research efforts. We are also thankful to Dr. John F. Eng at Princeton University for his help with HRMS analysis.
Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2016/11
Y1 - 2016/11
N2 - Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted β-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.
AB - Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted β-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.
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U2 - 10.1002/ejoc.201601093
DO - 10.1002/ejoc.201601093
M3 - Article
AN - SCOPUS:84995426688
VL - 2016
SP - 5345
EP - 5349
JO - Annalen der Pharmacie
JF - Annalen der Pharmacie
SN - 0075-4617
IS - 32
ER -