Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters

Ian J. Bakanas, Gustavo Moura-Letts

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    7 Scopus citations

    Abstract

    Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted β-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.

    Original languageEnglish (US)
    Pages (from-to)5345-5349
    Number of pages5
    JournalEuropean Journal of Organic Chemistry
    Volume2016
    Issue number32
    DOIs
    StatePublished - Nov 2016

    All Science Journal Classification (ASJC) codes

    • Physical and Theoretical Chemistry
    • Organic Chemistry

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