Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters

Ian J. Bakanas, Gustavo Moura

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted β-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.

Original languageEnglish (US)
Pages (from-to)5345-5349
Number of pages5
JournalEuropean Journal of Organic Chemistry
Volume2016
Issue number32
DOIs
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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