Abstract
Herein we report the first redox-neutral visible-light photocatalytic intermolecular dipolar cycloaddition for the diastereoselective synthesis of isoxazolidines. We have found that vinyl nitrones with a diverse substitution pattern undergo visible-light-promoted cycloadditions with conjugated carbonyls in the presence of catalytic amounts of Ru(bpy)3Cl2, with the reaction proceeding with high yields and good selectivities. A redox-neutral pathway is proposed as the primary photoredox mechanism for this transformation.
Original language | English (US) |
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Article number | e202200277 |
Journal | ChemPhotoChem |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2023 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Physical and Theoretical Chemistry
- Organic Chemistry