Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

Subash C. Jonnalagadda, Jonathan S. Cruz, Ryan J. Connell, Patricia M. Scott, Venkatram R. Mereddy

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.

Original languageEnglish (US)
Pages (from-to)4314-4317
Number of pages4
JournalTetrahedron Letters
Issue number30
StatePublished - Jul 29 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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