Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

Subash C. Jonnalagadda; Jonathan S. Cruz; Ryan J. Connell; Patricia M. Scott; Venkatram R. Mereddy

doi:10.1016/j.tetlet.2009.05.026

Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

Subash C. Jonnalagadda, Jonathan S. Cruz, Ryan J. Connell, Patricia M. Scott, Venkatram R. Mereddy

Chemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.

Original language	English (US)
Pages (from-to)	4314-4317
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2009.05.026
State	Published - Jul 29 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.05.026

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title = "Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents",

abstract = "Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.",

author = "Jonnalagadda, {Subash C.} and Cruz, {Jonathan S.} and Connell, {Ryan J.} and Scott, {Patricia M.} and Mereddy, {Venkatram R.}",

note = "Funding Information: We thank the Departments of Chemistry and Biochemistry, Rowan University, and University of Minnesota Duluth for the resources and funding. Partial support for this work was provided by research grants from the National Institutes of Health (CA129993) (VRM) and Whiteside Institute for Clinical Research (VRM).",

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T1 - Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

AU - Jonnalagadda, Subash C.

AU - Cruz, Jonathan S.

AU - Connell, Ryan J.

AU - Scott, Patricia M.

AU - Mereddy, Venkatram R.

N1 - Funding Information: We thank the Departments of Chemistry and Biochemistry, Rowan University, and University of Minnesota Duluth for the resources and funding. Partial support for this work was provided by research grants from the National Institutes of Health (CA129993) (VRM) and Whiteside Institute for Clinical Research (VRM).

PY - 2009/7/29

Y1 - 2009/7/29

N2 - Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.

AB - Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

Abstract

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