Swelling behaviour and controlled drug release from cross-linked -carrageenan/NaCMC hydrogel by diffusion mechanism

Hadi Hezaveh, Ida Idayu Muhamad, Iman Noshadi, Lim Shu Fen, Norzita Ngadi

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


We studied a model system of controlled drug release using beta-carotene and -carrageenan/NaCMC hydrogel as a drug and a device, respectively. Different concentrations of genipin were added to crosslink the beta-carotene loaded beads by using the dripping method. Results have shown that the cross-linked beads possess lower swelling ability in all pH conditions (pH 1.2 and 7.4), and swelling ratio decreases with increasing genipin concentration. Microstructure study shows that cross-linking has enhanced the stability and structure of the beads network. Determination of diffusion coefficient for the release of encapsulated beta-carotene indicates less diffusivity when beads are cross-linked. Swelling models using adaptive neuro fuzzy show that using genipin as a cross-linker in the kC/NaCMC hydrogels affects the transport mechanism. The model shows very good agreement with the experimental data that indicates that applying ANFIS modelling is an accurate, rapid and simple way to model in such a case for controlled release applications.

Original languageEnglish (US)
Pages (from-to)368-379
Number of pages12
JournalJournal of Microencapsulation
Issue number4
StatePublished - Jun 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry


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