Structure of the pericentric long arm region of the human Y chromosome

Katrina F. Cooper; Richard B. Fisher; Chris Tyler-Smith

doi:10.1016/0022-2836(92)90831-4

Structure of the pericentric long arm region of the human Y chromosome

Katrina F. Cooper, Richard B. Fisher, Chris Tyler-Smith

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

We have analysed the sequence organization of the DNA in the pericentric region of the long arm of the human Y chromosome. The structures of one cosmid and three yeast artificial chromosome clones were determined. The region consists of a mosaic of the known 5, 48 and 68 base-pair tandemly repeated sequences and at least five novel repeated sequence families. A long range-map of approximately 3.5 × 10⁶ base-pairs of genomic DNA was constructed that placed the clones between about 500 × 10³ and 850 × 10³ base-pairs from the long arm edge of the centromeric alphoid DNA array.

Original language	English (US)
Pages (from-to)	421-432
Number of pages	12
Journal	Journal of Molecular Biology
Volume	228
Issue number	2
DOIs	https://doi.org/10.1016/0022-2836(92)90831-4
State	Published - Nov 20 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Structural Biology
Molecular Biology

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10.1016/0022-2836(92)90831-4

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title = "Structure of the pericentric long arm region of the human Y chromosome",

abstract = "We have analysed the sequence organization of the DNA in the pericentric region of the long arm of the human Y chromosome. The structures of one cosmid and three yeast artificial chromosome clones were determined. The region consists of a mosaic of the known 5, 48 and 68 base-pair tandemly repeated sequences and at least five novel repeated sequence families. A long range-map of approximately 3.5 × 106 base-pairs of genomic DNA was constructed that placed the clones between about 500 × 103 and 850 × 103 base-pairs from the long arm edge of the centromeric alphoid DNA array.",

author = "Cooper, \{Katrina F.\} and Fisher, \{Richard B.\} and Chris Tyler-Smith",

note = "Funding Information: We thank the individuals who have provided cell lines or probes, and William Brown, Zoia Larin and Ed Southern for comments on the manuscript. K.F.C. was supported by the MRC, R.B.F. was supported by the CRC and the EC. and C.T.S. was supported by the CRC.",

year = "1992",

month = nov,

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doi = "10.1016/0022-2836(92)90831-4",

language = "English (US)",

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TY - JOUR

T1 - Structure of the pericentric long arm region of the human Y chromosome

AU - Cooper, Katrina F.

AU - Fisher, Richard B.

AU - Tyler-Smith, Chris

N1 - Funding Information: We thank the individuals who have provided cell lines or probes, and William Brown, Zoia Larin and Ed Southern for comments on the manuscript. K.F.C. was supported by the MRC, R.B.F. was supported by the CRC and the EC. and C.T.S. was supported by the CRC.

PY - 1992/11/20

Y1 - 1992/11/20

N2 - We have analysed the sequence organization of the DNA in the pericentric region of the long arm of the human Y chromosome. The structures of one cosmid and three yeast artificial chromosome clones were determined. The region consists of a mosaic of the known 5, 48 and 68 base-pair tandemly repeated sequences and at least five novel repeated sequence families. A long range-map of approximately 3.5 × 106 base-pairs of genomic DNA was constructed that placed the clones between about 500 × 103 and 850 × 103 base-pairs from the long arm edge of the centromeric alphoid DNA array.

AB - We have analysed the sequence organization of the DNA in the pericentric region of the long arm of the human Y chromosome. The structures of one cosmid and three yeast artificial chromosome clones were determined. The region consists of a mosaic of the known 5, 48 and 68 base-pair tandemly repeated sequences and at least five novel repeated sequence families. A long range-map of approximately 3.5 × 106 base-pairs of genomic DNA was constructed that placed the clones between about 500 × 103 and 850 × 103 base-pairs from the long arm edge of the centromeric alphoid DNA array.

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JF - Journal of Molecular Biology

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ER -

Structure of the pericentric long arm region of the human Y chromosome

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