Structure of the pericentric long arm region of the human Y chromosome

Katrina F. Cooper, Richard B. Fisher, Chris Tyler-Smith

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


We have analysed the sequence organization of the DNA in the pericentric region of the long arm of the human Y chromosome. The structures of one cosmid and three yeast artificial chromosome clones were determined. The region consists of a mosaic of the known 5, 48 and 68 base-pair tandemly repeated sequences and at least five novel repeated sequence families. A long range-map of approximately 3.5 × 106 base-pairs of genomic DNA was constructed that placed the clones between about 500 × 103 and 850 × 103 base-pairs from the long arm edge of the centromeric alphoid DNA array.

Original languageEnglish (US)
Pages (from-to)421-432
Number of pages12
JournalJournal of Molecular Biology
Issue number2
StatePublished - Nov 20 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology


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