Strain differences in convulsive response to the excitotoxin kainic acid

Gregory T. Golden, George G. Smith, Thomas N. Ferraro, Patricio F. Reyes, James K. Kulp, Ruggero G. Fariello

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

We describe a strain of rats (Wistar-Furth) that is highly susceptible to the neurotoxic effects of kainic acid (KA) and presents a reliable and quantifiable (with low within-group variability) animal model of status epilepticus. Wistar-Furth rats are more sensitive and demonstrate a less variable convulsant response than Sprague-Dawley and Long-Evans rats when tested for total time in seizure activity, latency to onset of first seizure, latency to status epilepticus, seizure severity scores, and percentage exhibiting behavioral seizures and status epilepticus. Results suggest that significant heterogeneity exists in the rodent population with regard to neuronal sensitivity to an excitotoxic amino acid and indicate that strain differences are an important consideration in studies using KA.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalNeuroReport
Volume2
Issue number3
DOIs
StatePublished - Mar 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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