TY - JOUR
T1 - Standardizing ADOS scores for a measure of severity in autism spectrum disorders
AU - Gotham, Katherine
AU - Pickles, Andrew
AU - Lord, Catherine
N1 - Funding Information:
Acknowledgments We gratefully acknowledge the help of Susan Risi, Kathryn Larson, Cristina Popa, and Mary Yonkovit, as well as the families that participated in this research. This study was funded by the National Institute of Mental Health (Validity of Diagnostic Measures for Autism Spectrum Disorders: NIMH RO1 MH066469) and an Autism Speaks Predoctoral Training Fellowship.
PY - 2009/5
Y1 - 2009/5
N2 - The aim of this study is to standardize Autism Diagnostic Observation Schedule (ADOS) scores within a large sample to approximate an autism severity metric. Using a dataset of 1,415 individuals aged 2-16 years with autism spectrum disorders (ASD) or nonspectrum diagnoses, a subset of 1,807 assessments from 1,118 individuals with ASD were divided into narrow age and language cells. Within each cell, severity scores were based on percentiles of raw totals corresponding to each ADOS diagnostic classification. Calibrated severity scores had more uniform distributions across developmental groups and were less influenced by participant demographics than raw totals. This metric should be useful in comparing assessments across modules and time, and identifying trajectories of autism severity for clinical, genetic, and neurobiological research.
AB - The aim of this study is to standardize Autism Diagnostic Observation Schedule (ADOS) scores within a large sample to approximate an autism severity metric. Using a dataset of 1,415 individuals aged 2-16 years with autism spectrum disorders (ASD) or nonspectrum diagnoses, a subset of 1,807 assessments from 1,118 individuals with ASD were divided into narrow age and language cells. Within each cell, severity scores were based on percentiles of raw totals corresponding to each ADOS diagnostic classification. Calibrated severity scores had more uniform distributions across developmental groups and were less influenced by participant demographics than raw totals. This metric should be useful in comparing assessments across modules and time, and identifying trajectories of autism severity for clinical, genetic, and neurobiological research.
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U2 - 10.1007/s10803-008-0674-3
DO - 10.1007/s10803-008-0674-3
M3 - Article
C2 - 19082876
AN - SCOPUS:67349117273
SN - 0162-3257
VL - 39
SP - 693
EP - 705
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 5
ER -