Stacked generalization for early diagnosis of Alzheimer's disease

Hardik Gandhi, Deborah Green, John Kounios, Christopher M. Clark, Robi Polikar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

The diagnosis of Alzheimer's disease (AD) at an early stage is a major concern due to growing number of elderly population affected by the disease, as well as the lack of a standard diagnosis procedure available to community clinics. Recent studies have used wavelets and other signal processing methods to analyze EEG signals in an attempt to find a noninvasive biomarker for AD. These studies had varying degrees of success, in part due to small cohort size. In this study, multiresolution wavelet analysis is performed on event related potentials of the EEGs of a relatively larger cohort of 44 patients. Particular emphasis was on diagnosis at the earliest stage and feasibility of implementation in a community health clinic setting. Extracted features were then used to train an ensemble of classifiers based stacked generalization approach. We describe the approach, and present our promising preliminary results.

Original languageEnglish (US)
Title of host publication28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages5350-5353
Number of pages4
DOIs
StatePublished - Dec 1 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Gandhi, H., Green, D., Kounios, J., Clark, C. M., & Polikar, R. (2006). Stacked generalization for early diagnosis of Alzheimer's disease. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 (pp. 5350-5353). [4030428] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2006.260644