TY - JOUR
T1 - Stabilization of vaccines and antibiotics in silk and eliminating the cold chain
AU - Zhang, Jeney
AU - Pritchard, Eleanor
AU - Hu, Xiao
AU - Valentin, Thomas
AU - Panilaitis, Bruce
AU - Omenetto, Fiorenzo G.
AU - Kaplan, David L.
PY - 2012/7/24
Y1 - 2012/7/24
N2 - Sensitive biological compounds, such as vaccines and antibiotics, traditionally require a time-dependent "cold chain" to maximize therapeutic activity. This flawed process results in billions of dollars worth of viable drug loss during shipping and storage, and severely limits distribution to developing nations with limited infrastructure. To address these major limitations, we demonstrate selfstanding silk protein biomaterial matrices capable of stabilizing labile vaccines and antibiotics, even at temperatures up to 60 ° C over more than 6 months. Initial insight into the mechanistic basis for these findings is provided. Importantly, these findings suggest a transformative approach to the cold chain to revolutionize the way many labile therapeutic drugs are stored and utilized throughout the world.
AB - Sensitive biological compounds, such as vaccines and antibiotics, traditionally require a time-dependent "cold chain" to maximize therapeutic activity. This flawed process results in billions of dollars worth of viable drug loss during shipping and storage, and severely limits distribution to developing nations with limited infrastructure. To address these major limitations, we demonstrate selfstanding silk protein biomaterial matrices capable of stabilizing labile vaccines and antibiotics, even at temperatures up to 60 ° C over more than 6 months. Initial insight into the mechanistic basis for these findings is provided. Importantly, these findings suggest a transformative approach to the cold chain to revolutionize the way many labile therapeutic drugs are stored and utilized throughout the world.
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U2 - 10.1073/pnas.1206210109
DO - 10.1073/pnas.1206210109
M3 - Article
C2 - 22778443
AN - SCOPUS:84864364745
SN - 0027-8424
VL - 109
SP - 11981
EP - 11986
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 30
ER -