Stabilization of vaccines and antibiotics in silk and eliminating the cold chain

Jeney Zhang, Eleanor Pritchard, Xiao Hu, Thomas Valentin, Bruce Panilaitis, Fiorenzo G. Omenetto, David L. Kaplan

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Sensitive biological compounds, such as vaccines and antibiotics, traditionally require a time-dependent "cold chain" to maximize therapeutic activity. This flawed process results in billions of dollars worth of viable drug loss during shipping and storage, and severely limits distribution to developing nations with limited infrastructure. To address these major limitations, we demonstrate selfstanding silk protein biomaterial matrices capable of stabilizing labile vaccines and antibiotics, even at temperatures up to 60 ° C over more than 6 months. Initial insight into the mechanistic basis for these findings is provided. Importantly, these findings suggest a transformative approach to the cold chain to revolutionize the way many labile therapeutic drugs are stored and utilized throughout the world.

Original languageEnglish (US)
Pages (from-to)11981-11986
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number30
DOIs
StatePublished - Jul 24 2012

All Science Journal Classification (ASJC) codes

  • General

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