Src Points the Way to Biomarkers and Chemotherapeutic Targets

Harini Krishnan, W. Todd Miller, Gary S. Goldberg

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The role of Src in tumorigenesis has been extensively studied since the work of Peyton Rous over a hundred years ago. Src is a non-receptor tyrosine kinase that plays key roles in signaling pathways controlling tumor cell growth and migration. Src regulates the activities of numerous molecules to induce cell transformation. However, transformed cells do not always migrate and realize their tumorigenic potential. They can be normalized by surrounding nontransformed cells by a process called contact normalization. Tumor cells need to override contact normalization to become malignant or metastatic. In this review, we discuss the role of Src in cell migration and contact normalization, with emphasis on Cas and Abl pathways. This paradigm illuminates several chemotherapeutic targets and may lead to the identification of new biomarkers and the development of effective anticancer treatments.

Original languageEnglish (US)
Pages (from-to)426-435
Number of pages10
JournalGenes and Cancer
Volume3
Issue number5-6
DOIs
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

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