Src and podoplanin forge a path to destruction

Harini Krishnan, W. Todd Miller, Francisco J. Blanco, Gary S. Goldberg

    Research output: Contribution to journalReview articlepeer-review

    9 Scopus citations

    Abstract

    Cancer and arthritis present an enormous challenge to society. They share pathogenic pathways that involve extracellular matrix degradation, tissue invasion, and inflammation. Most cancer and arthritis treatments affect normal cell function to cause significant adverse effects in patients. Specific pathways that promote cancer and arthritis progression must be elucidated to design more targeted and effective therapeutics. The Src kinase and podoplanin (PDPN) receptor are upregulated in cancer cells, fibroblasts, synoviocytes, and immune cells that increase tissue invasion and inflammation to promote both cancer and arthritis. In this review, we discuss how Src and PDPN forge a path to tissue destruction, and how they can serve as targets for therapeutics to combat cancer and arthritis.

    Original languageEnglish (US)
    Pages (from-to)241-249
    Number of pages9
    JournalDrug Discovery Today
    Volume24
    Issue number1
    DOIs
    StatePublished - Jan 2019

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Drug Discovery

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