The leukocyte migration test (LMT) reactivity of breast cancer patients to RIII murine mammary tumor virus (MuMTV) gp55 was studied and compared with simultaneous reactivity to the following: (a) RIII gp55 prepared in another laboratory; (b) gp68, gp34, and p28 of RIII MuMTV; (c) gp50 of A-strain MuMTV; (d) gp70 and gp45 of Rauscher leukemia virus; and (e) autologous and homologous lymphoreticuloendothelial (L-RE)-positive and-negative breast cancer tissues and extracts of MCF-7 tissue culture cells. LMT reactivity against the two gp55 preparations was essentially identical. A similar correlation was found in regard to LMT reactivity of L-RE-positive breast cancer patients, tested >11 months postoperatively against gp55 and autologous and homologous breast cancer tissues. Such a correlation was not demonstrable between LMT reactivity to gp55 and reactivity to other RIII MuMTV protein fractions, gp50 of A-strain MuMTV, Rauscher leukemia virus protein fractions, or L-RE-negative autologous breast cancer tissues. LMT reactivity to MCF-7 extracts was essentially limited to patients who were responsive to gp55. It appears that LMT reactivity of breast cancer patients to gp55 does not reflect a nonspecific increase in cell-mediated immunity randomly directed against glycoproteins and breast cancer tissue. To the contrary, it appears that the observed simultaneous LMT reactivity to gp55 and L-RE-positive breast cancer tissues reflects antigenic similarity in their cell-mediated immunity determinants. Information regarding the molecular nature of the cell-mediated immunity determinants should be of conceptual and clinical significance.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Oct 1 1978|
All Science Journal Classification (ASJC) codes
- Cancer Research